The marine environment is a prolific resource for the isolation of less exploited microbes. Owing to the nature of this environment, there is a strong competition among microbes for space and nutrients that endows them to produce natural products possessing medical and industrial value. The present study was undertaken to discover novel antibacterial compounds from marine bacterial sources for the treatment of ever-increasing drug-resistant infections. A total of 150 isolates obtained from different marine sources were screened for their antibacterial activity using the agar well diffusion method. Nine of the isolates were found to exhibit antibacterial activity. The current data reports the preliminary screening of the antimicrobial effect of the Cell-Free Supernatant (CFS) of these nine isolates against six pathogenic microbes. This study is an attempt to isolate diverse marine bacteria that exhibit significant biological activity that could be an important lead in the search for novel natural products of clinical importance

Antibacterial activity, marine, CFS, Agar well diffusion method