An experiment was conducted for 60 days to evaluate the growth performance and survival of Cyprinus carpio in inland saline water (ISW). One hundred twenty acclimatized fingerlings (average body weight- 5±0.5 g) were distributed between two treatments (FW-0.5 ppt and ISW-5ppt) in four replicates fed with control diet. The fishes reared in ISW showed significantly lower (p<0.05) weight gain percentage, and PER than the fishes reared in freshwater (FW). The metabolic enzyme activities (AST and ALT and glucose-6 phosphatase) in the liver was significantly higher (p<0.05) in the ISW group. These results revealed that the rearing of common carp in 5 ppt ISW results in significant reduction (p<0.05) in growth and increased metabolic stress. Even though there was a 10% reduction (p<0.05) in growth in common carp after rearing in ISW, the study reveals 100% survival of the fish. Thus, it can be inferred that common carp can be reared in inland saline water, which shows a prospective way to utilize the ISW for aquaculture

Digestive enzymes, metabolic enzymes, oxidative stress enzymes